Association analyses of metabolic syndrome and the serum gamma glutamyltransferase or alanine aminotransferase / 中国医师杂志

ABSTRACT

Objective To explore the direct association between metabolic syndrome (MS) and gamma glutamyltransferase (GGT) or alanine aminotransferase (ALT) in Beijing men and women.Methods We investigated the medical check-up data from the 14,204 physical examination population (male 9524,female 4680) of year 2008.A cross-sectional study was carried out to explore the direct association between MS and GGT or ALT.MS was defined by the Chinese Diabetes Society (2004).Chisquare test was performed to analyze the categorical variables.The receiver operating characteristic curve (ROC) was plotted to obtain area under curve (AUC) and the cutoff point of GGT and ALT.Results The prevalence of MS was significantly higher in subjects with the highest quartile of GGT or ALT than the subjects with the lowest quartile of GGT or ALT.For male,the prevalence of MS is 7.57％ in the lowest GGT quartile and 29.04％ in the highest GGT quartile.For female,the prevalence of MS is 1.28％ in the lowest GGT quartile and 17.86％ in the highest GGT quartile.For male,the prevalence of MS is 9.27％ in the lowest ALT quartile and 21.88％ in the highest ALT quartile.For female,the prevalence of MS is 3.52％ in the lowest ALT quartile and 14.70％ in the highest ALT quartile (P ＜0.01).The optimal cutoff points of GGT to diagnose MS were 31 U/L in men and 18 U/L in women.The optimal cutoff points of ALT to diagnose MS were 23 U/L in men and 19 U/L in women.Conclusions The prevalence of MS increases with the increase in serum levels of GGT or ALT even through the normal range of GGT or ALT in Chinese men and women.