The Innate Immune Response in House Dust Mite-Induced Allergic Inflammation
Allergy, Asthma & Immunology Research
;
: 68-74, 2013.
Article
in English
| WPRIM
| ID: wpr-42981
ABSTRACT
Hypersensitivity to house dust mite (HDM; Dermatophagoides sp.) allergens is one of the most common allergic responses, affecting up to 85% of asthmatics. Sensitization to indoor allergens is the strongest independent risk factor associated with asthma. Additionally, >50% of children and adolescents with asthma are sensitized to HDM. Although allergen-specific CD4+ Th2 cells orchestrate the HDM allergic response through induction of IgE directed toward mite allergens, activation of innate immunity also plays a critical role in HDM-induced allergic inflammation. This review highlights the HDM components that lead to activation of the innate immune response. Activation may due to HDM proteases. Proteases may be recognized by protease-activation receptors (PARs), Toll-like receptors (TLRs), or C-type lectin receptors (CTRs), or act as a molecular mimic for PAMP activation signaling pathways. Understanding the role of mite allergen-induced innate immunity will facilitate the development of therapeutic strategies that exploit innate immunity receptors and associated signaling pathways for the treatment of allergic asthma.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Peptide Hydrolases
/
Asthma
/
Dendritic Cells
/
Immunoglobulin E
/
Allergens
/
Risk Factors
/
Th2 Cells
/
Pyroglyphidae
/
Lectins, C-Type
/
Dust
Type of study:
Etiology study
/
Risk factors
Limits:
Adolescent
/
Child
/
Humans
Language:
English
Journal:
Allergy, Asthma & Immunology Research
Year:
2013
Type:
Article
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