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Analysis of treatment outcome for stage Ⅲ thymoma / 中华放射肿瘤学杂志
Chinese Journal of Radiation Oncology ; (6): 513-517, 2012.
Article in Chinese | WPRIM | ID: wpr-430118
ABSTRACT
Objective To analyze survival and recurrence rates of patients with Masaoka stage Ⅲ thymoma and to explore the prognostic factors.Methods Between September 1965 and December 2010,a total of 111 patients with stage Ⅲ thymoma treated in our hospital were retrospectively analyzed.Sixty-eight patientsreceived comple te rescction ± radiotherapy,whilc 23 patients received incomplete resection ±radiotherapy and 20 patients received biopsy ± radiotherapy.Eighty-seven patients received postoperative radiotherapy (12 patients received preoperative radiotherapy) while 24 patients received surgery alone.Results The median follow-up time was 66 months (5-540) with a follow-up rate of 92.5% (111/120).Compared with incomplete resection ± radiotherapy and biopsy ± radiotherapy,the 5-year overall survival (OS) (88% vs.59% and 57%,x2 =12.11,P =0.002),disease free survival (DFS) (74% vs.40% and 41%,x2 =11.49,P =0.003) and disease specific survival (DSS) (94% vs.69% and 60%,x2 =10.95,P =0.004) could be improved with complete resected ± radiotherapy.Compared with surgery alone,postoperative radiotherapy did not improve OS,DFS and DSS (55% vs.77% (x2 =1.01,P =0.316),61%vs.61% (x2 =0.12,P =0.729) and 72% vs.85% (x2 =0.27,P =0.601),respectively).For the 68 patients received complete resection,radiotherapy after complete resection (56 patients) did not improve OS,DFS and DSS (82% vs.89% (x2 =0.31,P =0.576),72% vs.81% (x2 =0.05,P=0.819) and 89%vs.95 % (x2 =0.05,P =0.825),respectively) compared with surgery alone (8 patients).Conclusions Stage Ⅲ thymoma patients received complete resection had better outcome than patients received incomplete resection or biopsied only.The role of postoperative radiotherapy is still controversial for stage Ⅲ thymoma,randomized clinical trial is needed

Full text: Available Index: WPRIM (Western Pacific) Type of study: Controlled clinical trial / Prognostic study Language: Chinese Journal: Chinese Journal of Radiation Oncology Year: 2012 Type: Article

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Full text: Available Index: WPRIM (Western Pacific) Type of study: Controlled clinical trial / Prognostic study Language: Chinese Journal: Chinese Journal of Radiation Oncology Year: 2012 Type: Article