Stroke-induced immunodepression and stroke-associated infection / 国际脑血管病杂志

ABSTRACT

Stroke-associated infection is a leading cause of death in patients with stroke.Recent research indicated that stroke-induced immunodepression increases the susceptibility to infection.The immune system shows a biphasic change after stroke.Tne resident cells (mainly microglia) in the central nervous system are activated following stroke and produce pro-inflammatory cytokines and chemokines,which are involved in ischemic injury.Subsequent systemic immunodepression can result in increases susceptibility to infection,but it also facilitate neurogenesis.The ovcractivity of the sympathetic nervous system is the key to the development of immune suppression.The strategies for controlling stroke-associated infection include sympathetic antagonists,immunomodulators and prophylactic antibiotic therapy.