Expression and clinical significance of Survivin and Glut 1 protein in gastric carcinoma / 中国综合临床

ABSTRACT

Objective Toinvestigate the expression and clinical significance of Survivin and Glut 1 protein in gastric carcinoma.Methods In 78 gastric carcinoma specimen and 20 normal mucosa gastric specimen,the expression of Glut 1 and Survivin protein was detected by immunohistochemistry.The relationship between expression of Survivin and Glut 1 protein and clinical pathological parameters were analyzed.Results The rates of Survivin and Glut 1 protein expression were 75.64％ (59/78) and 78.21％ (61/78) respectively,which were significantly higher than those in normal gastric tissues(10.00％ (2/20) and 5.00％ (1/20),x2 =4.265,4.158,P ＜ 0.01).The expression of Survivin protein was not related to gender and age (P ＞ 0.05),but was associated with cellular differentiation,serosa infiltration,lymph node metastasis and TNM stage (x2 =4.143,4.247,11.813,7.542,P ＜ 0.05).The expression of Glut 1 protein was not related to gender,age,cellular differentiation and serosa infiltration (P ＞ 0.05),but was associated with lymph node metastasis and TNM stage(x2 =6.230,4.083,P ＜ 0.05).The expression of Survivin protein was positively correlated with Glut 1 protein(x2 =7.145,r =0.342,P ＜0.05).Conclusion Elevated levels of Survivin and Glutl protein play an important role in the carcinogenesis and development of gastric carcinoma.The measurement of Survivin and Glut 1 protein levels may be effective parameters for predicting the biological behavior and prognosis of gastric carcinoma patients.