Relationship between estrogen receptor α and β expression and clinicopathological characteristics in elderly patients with non-small cell lung cancer / 中华老年医学杂志

ABSTRACT

Objective To evaluate estrogen receptor (ER) α and β expressions in elderly patients with non-small cell lung cancer (NSCLC) in China and their relationship with clinical and pathological characteristics.Methods Expressions of ER α and β were detected by immunohistochemical assay in 147 NSCLC patients over 65 years old,and its relationship with clinical and pathological characteristics was analyzed statistically.Results Both ERα and β expressed in nucleus.The positive expression rate of ER α and β was 4.1％ (6/147) and 86.4％ (127/147) respectively.There was correlation between ER α expression and the patient age,tumor stage,and pathology differential degree.There was higher ER α expression in patients 65 to 70 years old (8.8 ％) compared with patients over 70 years old (0.0％) (x2 =7.267,P=0.007).The ER α expression was higher in patients in stage Ⅰ (9.4％) than that in later stage (0.0％) (x2=8.112,P=0.004),and also higher in patients with pathological high degree (14.3％) than that with pathological low degree (0.0％) (x2=7.820,P=0.005).ER β expression was associated with tumor stage,histology type and pathology differential degree.ER β expression was higher in patients in stage Ⅰ (76.6 ％,x2 =9.322,P=0.002),much stronger in adenocarcinoma (71.0％,x2 =4.626,P=0.031),and in pathological high degree patients (82.1％,x2 =7.092,P =0.008).Conclusions ER α and β expressions correlate with clinical and pathological characteristics in elderly NSCLC patients.It indicates that expressions of ERα and β might play an important role in the occurrence and development of NSCLC,and might be a new therapy target in NSCLC.