Expression of serum VEGF in patient with bladder transitional cell carcinoma and its relationship with clinicopathological parameters / 中国基层医药

ABSTRACT

Objective To investigate the expression of serum vascular endothelial growth factor(VEGF) in patient with bladder transitional cell carcinoma (BTCC) and its relationship with clinicopathological parameters.Methods The clinical data of 68 patients with BTCC who underwent surgical treatment was retrospectively analyzed,the healthy subjects was considered as control group,the serum VEGF levels of patient with BTCC and healthy subjects were detected by ELISA and compared.Results The VEGF levels of bladder cancer group was (317.62 ±89.47) ng/L,and was significantly higher than that of the control group [(53.08 ± 17.40) ng/L] (t =16.017,P ＜0.01).The VEGF levels of invasive cancer group and pathological grading of high-level group were respectively higher than the superficial tumor group and pathological grading of low-level group,compared the difference was significant (t =8.191,6.230,all P ＜0.01).The VEGF level was not significantly difference between the different age groups,gender groups and tumor size groups(t =0.423,0.528,1.307,all P ＞ 0.05).Conclusion The serum VEGF levels are high expression in patients with BTCC,the VEGF levels are closely related to clinical stage and histological grade.The high expression of serum VEGF shows the invasion and progression of BTCC.