Research progress of FLIP in cancer / 国际肿瘤学杂志
Journal of International Oncology
; (12): 83-85, 2013.
Article
in Zh
| WPRIM
| ID: wpr-431509
Responsible library:
WPRO
ABSTRACT
FLIP is a protein containing death domain.Human beings have three subtypes of c-FLIPL,c-FLIPs and c-FLIPR,which can inhibit the apoptosis of a variety of tumor cells.c-FLIPL plays a dual role in the apoptotic signal.The expression level of FLIP not only decides the opening and closing of the apoptosis pathway but also achieve the conversion of cells in the apeptotic signaling and proliferative signaling pathway.The regulation of FLIP's expression is a multi-layered,involving multiple signaling pathways.FLIP will probably become an attractive death receptor signaling target of therapy.
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WPRIM
Language:
Zh
Journal:
Journal of International Oncology
Year:
2013
Type:
Article