The Roles of Intercellular Adhesion Molecule I in T Cell Adhesion Tosynovial Cell in Patients with Rheumatoid Arthritis / 대한류마티스학회지
The Journal of the Korean Rheumatism Association
;
: 119-125, 1995.
Article
in Korean
| WPRIM
| ID: wpr-43160
ABSTRACT
OBJECTIVE:
It has previously been shown that cellular interaction between infiltrating mononuclear cells and synoviocyte are important in the initiation and perpetuation of autoimmune processes in the synovial tissue of patients with rheuamtoid arthritis. Thus, we have investigated the molecular basis of T cell-synovial cell interaction in the cultured synoviocytes from patients with rheumatoid arthritis.METHODS:
Using an immunohistochemical staining technique and inhibition study with monoclonal antibody, we studied the expression and the function of intercellular adhesion molecule 1 (ICAM-1) in T cell-synovial cell interaction in the cultured synoviocytes.RESULTS:
Expression of ICAM-1 was diffusely observed in most components of rheumatoid synovium and readily up-regulated by IL-1. T cell-synovial cell interaction was inhibited by monoclehal antibody aganinst ICAM-1.CONCLUSION:
These results showed that ICAM-1 was involed in the cellular interaction between T lymphocytes and synovial cells in patients with rheumatoid arthritis.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Arthritis
/
Arthritis, Rheumatoid
/
Synovial Membrane
/
T-Lymphocytes
/
Cell Adhesion
/
Cell Communication
/
Interleukin-1
/
Intercellular Adhesion Molecule-1
Limits:
Humans
Language:
Korean
Journal:
The Journal of the Korean Rheumatism Association
Year:
1995
Type:
Article
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