Observation on the effect of seculin combined with traditional Chinese medicine on the treatment of depression / 中国基层医药

ABSTRACT

Objective To observe the effect of sertraline combined with traditional Chinese medicine in the treatment of depression.Methods 80 patients with major depression by the order of lottery were randomly divided into two groups,each 40 cases.The control group were treated with sertraline.The treatment based on the control group were treated with traditional Chinese medicine.The two groups were observed for 6 weeks.Bafore treatment and 1 week,2 weeks,4 weeks,6 weesk,after treatment.the antidepressant efficacy was evaluated by HAMD score.Adverse effects were recorded.Results Total effectiveness of the treatment group and the control group were 82.5％,60.0％,respectively two groups had statistical significance(x2 =4.943,P ＜ 0.05).Compared with before treatment the HAM D score of treatment group 1 weekend were significantly decreased (t =10.627,P ＜ 0.01),the control group after 2 weeks treatment decreased significantly.Two groups of adverse reaction rate had a significant difference(x2 =5.952,P ＜ 0.05).Conclusion Yangxin spleen,soothe the nerves of Chinese medicine combined with western medicine in the treatment of depression relieving effect is better than that of single use of sertraline,faster onset of action,with less adverse reactions.