A case of Waldenström's macroglobulinemia treated using clarithromycin and prednisolone
Translational and Clinical Pharmacology
;
: 134-137, 2017.
Article
in English
| WPRIM
| ID: wpr-43199
ABSTRACT
We report a case of Waldenström's macroglobulinemia (WM) treated using clarithromycin (CAM) and prednisolone (PSL). An 84-year-old woman was admitted to our hospital for bleeding after a tooth extraction and hematuria. Computed tomography showed multiple ill-defined nodules in the omentum (omental cake). Although the cause of the omental cake remained unclear, the patient was diagnosed with WM, based on the detection of M-protein of immunoglobulin (Ig) M in serum and lymphoplasmacytes in bone marrow. The bleeding tendency in the patient may have been due to acquired hemophilia and/or hyper IgM-induced platelet dysfunction. The patient was treated using CAM (800 mg/day) and PSL (10 mg/day). As a result, IgM levels gradually decreased. Because the omental cake contracted along with improvement in IgM, it was thought to be lymphoplasmacytic lymphoma-like lymphoma. This case shows that treatment using CAM and PSL may be effective in some cases of WM.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Omentum
/
Tooth Extraction
/
Blood Platelets
/
Bone Marrow
/
Immunoglobulin M
/
Immunoglobulins
/
Prednisolone
/
Waldenstrom Macroglobulinemia
/
Clarithromycin
/
Hematuria
Limits:
Aged
/
Aged80
/
Female
/
Humans
Language:
English
Journal:
Translational and Clinical Pharmacology
Year:
2017
Type:
Article
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