Progress in the influences of calcineurin and transient receptor potential cation channel 6 on podocyte cytoskeleton / 国际儿科学杂志

ABSTRACT

Podocyte is a crucial part of glomerular filtration barrier,whose injury usually cause proteinufla.The structural and functional integrity of podocyte cytoskeleton is a prerequisite for its normal physiological function,and injury of actin-centered cytoskeleton is thought to be the final common path of the foot process fusion of podocyte.Calcineurin(CaN) is a research focus since it was discovered to be the target of cyclospofine and tacrolimus in 1991,while TRPC6 was a newly found protein located at slit diaphragm,a zip-like structure formed by adjacent interdigitated foot process.New evidences support that CaN and TRPC6 mediate injury of podocyte cytoskeleton,interestingly,interactions between CaN and TRPC6 also play a role in regulating cytoskeleton,which remain unrevealed mostly.This review aims to summary the new progress of influences of CaN and TRPC6 on cytoskeleton.