Progress on the molecular mechanisms of neuroglobin improving neonatal hypoxia-isehemia brain injury / 国际儿科学杂志
International Journal of Pediatrics
;
(6): 142-144, 2013.
Article
in Chinese
| WPRIM
| ID: wpr-432476
ABSTRACT
Neuroglobin is involved in neuroprotection from damage due to hypoxia or ischemia in vitro and in vivo.Overexpression of neuroglobin ameliorates the recovery from hypoxia-ischemia brain injury in experimental animals.The mechanism is still unknown.Studies have revealed that neuroglobin has a typical globin fold,and despite being hexacoordinated,which binds reversibly O2,CO2,and NO.This article reviews the possible mechanisms involved in neuroprotection of neuroglobin and provide a clue in treatment of hypoxia-ischemia brain injury.
Full text:
Available
Index:
WPRIM (Western Pacific)
Language:
Chinese
Journal:
International Journal of Pediatrics
Year:
2013
Type:
Article
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