Expression and Relationship of OPN and MMP-9 in Epithelial Ovarian Carcinoma / 中国医科大学学报
Journal of China Medical University
;
(12): 775-777, 2009.
Article
in Chinese
| WPRIM
| ID: wpr-432522
ABSTRACT
Objective To study the expression and relationship of osteopontin (OPN) and matrix metalloproteinase-9 (MMP-9) in epithe-lial ovarian carcinoma. Methods Immunohistochemical staining S-P methods was used to detect the expression of OPN and MMP-9 in the samples of 60 epithelial ovarian carcinoma,20 benign ovarian tumor,20 borderline ovarian tumor and 10 normal ovarian tissue. Results The expression level of OPN and MMP-9 in epithelial ovarian carcinoma(109.86±21.51) were significantly higher than those in borderline ovarian tumor(45.81±8.93),benign ovarian tumor(11.86±3.01) and normal ovarian tissue(5.32±2.74). The expression level of OPN and MMP-9 related to the tumor grading,tumor stage and lymph node metastasis,while had no relationship with histological grading. There was significant positive correlation between OPN and MMP-9 in epithelial ovarian carcinoma (r = 0.80,P < 0.05). Conclusion The increased expression of OPN and MMP-9 may play an important role in the process of carcinogenesis, progression and differentiation of epithelial ovari-an carcinoma. OPN and MMP-9 may be a useful targets for treatment of ovarian carcinoma.
Full text:
Available
Index:
WPRIM (Western Pacific)
Language:
Chinese
Journal:
Journal of China Medical University
Year:
2009
Type:
Article
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