Expression of Cyclooxygenase-2 in Helicobacter pylori-infected Gastric Cancer and Its Effect on the Invasion and Metastasis of Gastric Cancer / 中国医科大学学报
Journal of China Medical University
;
(12): 767-769, 2010.
Article
in Chinese
| WPRIM
| ID: wpr-432636
ABSTRACT
Objective To analyze the effect of cyclooxygenase-2(COX-2)on the invasion and metastasis of gastric cancer with Helicobacter pylori(H.pylori)infection.Methods A total of 60 gastric cancer specimens were included in this study.H.pylori infection was deter-mined by improved Giemsa method and the expression of COX-2 was examined by immunohistochemistry.The correlation between H.pylori infection and the clinical pathological features of gastric cancer was analyzed.Results H.pylori infection was detectable in 36 of 60 cases(60.0%),and correlated with the staging(χ2=28.040,P =0.000)and lymph node metastasis(χ2=25.482,P =0.000),but not with the age,sex of patients or histological types.H.pylori infection also significantly linked to the expression of COX-2(χ2=24.326,P 〈 0.001).Con-clusion H.pylori infection may promote the invasion and metastasis of gastric cancer by increasing the expression of COX-2.
Full text:
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Index:
WPRIM (Western Pacific)
Language:
Chinese
Journal:
Journal of China Medical University
Year:
2010
Type:
Article
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