Diagnostic value of procalcitonin and C-reactive protein in bronchial asthma complicated with respiratory infection / 中国医师进修杂志

ABSTRACT

Objective To explore the diagnostic value of serum procalcitonin(PCT) and C-reactive protein (CRP) in using of antibiotics in patients with acute bronchial asthma attack.Methods Sixty cases with acute bronchial asthma attack were divided into allergen-induced group (18 cases),viral infectioninduced group (14 cases) and bacteria infection-induced group (28 cases).The serum PCT level was examined by immune luminous method.The CRP level was examined by enzyme linked immune scattered method.Results The serum PCT and CRP level was (25.7 ± ll.2)μg/L and (50.3 ± 17.5) mg/L in bacteria infection-induced group,which was significantly higher than that in viral infection-induced group and allergen-induced group [(0.7 ± 0.2) μ g/L,(6.1 ± 0.3) mg/L and (0.2 ± 0.1) μ g/L,(3.5 ± 0.4) mg/L,P ＜ 0.05].There was no significant difference in the serum PCT and CRP level between viral infectioninduced group and allergen-induced group (P ＞ 0.05).There was positive correlation between PCT and CRP in bacterial infection group (r =0.932,P ＜ 0.05),while no correlation existed between PCT and CRP in viral infection-induced group and allergen-induced group (r =-0.021,-0.103,P＞0.05).CRP≥10 mg/L andPCT ≥0.5 μ g/L was as positive criteria.The positive rate of serum CRP and PCT in bacteria infection-induced group was 89.3％(25/28) and 92.9％(26/28),which was higher than that in viral infection-induced group and allergen-induced group [28.6％ (4/14),64.3％ (9/14) and 22.2％ (4/18),33.3％ (6/18),P ＜0.05],and the positive rate of serum CRP and PCT in viral infection-induced group was higher than that in allergen-induced group,there was significant difference (P ＜ 0.05).Conclusion The serum PCT and CRP level can correctly identify early bacteria infection patients with acute bronchial asthma attack.