Study on serum cancer antigens 125 expression in different types of ovarian endometriosis and related factors / 中国医师进修杂志

ABSTRACT

Objective To investigate serum cancer antigens (CA) 125 expression in different types of ovarian endometriosis and related factors.Methods A total of 182 patients with ovarian endometriosis was collected,then they were divided into two groupsovarian endometriosis combined with other parts of lesions (A group,88 cases),simple ovarian endometriosis group (B group,94 cases).And selected 100 healthy physical check-up women from the hospital outpatient department were as control group.The serum level of CA125 was detected.The patients' information including body shape,menstrual factors,reproductive activities and disease staging were collected.Chi-square criterion and multivariate binary Logistic regression analysis were completed.Results The serum levels of CA125 in A group,B group and control group were (48.64 ± 33.18),(41.35 ± 23.46),(22.16 ± 13.73) kU/L,respectively,and the positive expression rate of three groups were 64.77％ (57/88),52.13％ (49/94),2.00％ (2/100),respectively,there were significant differences (P ＜ 0.05).The multivariate binary Logistic regression analysis result showed that age of 35-49years,reforming American fertility society of Ⅲ-Ⅳ stage,pelvic adhesion and menorrhalgia were the important factors of positive expression of CA125.Conclusion The serum level of CA125 can be used as the evaluation of the diagnosis and treatment of ovarian endometriosis.