Change and clinical significance of insulin-like growth factor Ⅱ in patients with bone fractures accompnied by craniocerebral trauma / 中国医师进修杂志

ABSTRACT

Objective To study the change and clinical significance of insulin-like growth factor Ⅱ (IGF-Ⅱ) in patients with bone fractures accompanied by craniocerebral trauma.Methods The level of IGF-Ⅱ was detected by ELISA in 40 patients with bone fractures accompanied by craniocerebral trauma (combined with craniocerebral trauma group) and 40 patients of simple fracture (simple fracture group) after injury 1,3,7,14 d.Forty healthy person was as control group.The rate of porosis after injury 4,8,12 weeks was compared.Results The level of IGF-Ⅱ in combined with craniocerebral trauma group after injury 1,3,7,14 d was (4.15 + 1.38),(7.69 ± 2.40),(11.97 ± 3.74) and (14.08 ± 4.69) μg/L,simple fracture group was (2.56 ± 0.85),(3.70 ± 1.16),(4.96 + 1.55) and (7.52 ± 2.51) μg/L,control group was (2.10 ±0.70) μg/L.The level of IGF-Ⅱ in combined with craniocerebral trauma group and simple fracture group was significantly higher than that in control group (t =8.363,14.121,16.403,15.968;2.636,7.495,10.635,13.171,P ＜ 0.05).The level of IGF-Ⅱ in combined with craniocerebral trauma group was significantly higher than that in simple fracture group (t =6.187,9.449,10.950,7.799,P＜ 0.05).The rate of porosis after injury 4,8,12 weeks in combined with craniocerebral trauma group was 22.5％ (9/40),77.5％ (31/40),100.0％(40/40),significantly higher than that in simple fracture group [5.0％ (2/40),27.5％ (11/40),47.5％ (19/40)] (x2 =5.165,29.463,28.475,P ＜ 0.05).Conclusion The serum IGF-Ⅱ may become a new factor promoting the healing of fracture and this study provide new ideas for the treatment of fracture.