The expressions of vascular endothelial growth factor receptor and Periostin in floor-of-mouth squamous cancer and its clinical significance / 中国医师进修杂志

ABSTRACT

Objective To investigate the mRNA expressions of vascular endothelial growth factor receptor (VEGFR) and Periostin in floor-of-mouth squamous cancer and explore its clinical significance.Methods Cancer tissues of 64 floor-of-mouth squamous cancer patients were enrolled as observation group,and the adjacent normal tissues were collected as control group.The mRNA expressions of VEGFR and Periostin were detected by fluorescent quantitation PCR analysis.Results The mRNA expressions of VEGFR and Periostin in observation group were significantly higher than those in control group (0.514 ±0.142 vs.0.204 ± 0.086 and 0.502 ± 0.125 vs.0.184 ± 0.064,P ＜ 0.01).The mRNA expressions of VEGFR and Periostin had no significantly related with gender,and they were significantly related with histological grade,lymphatic metastasis and clinical pathologic stage (P ＜ 0.05).The mRNA expression of VEGFR was significantly positive related with the mRNA expressions of Periostin in floor-of-mouth squamous cancer tissues (r =0.624,P ＜0.01).Conclusions VEGFR and Periostin maybe play a key role in the development of floor-of-mouth squamous cancer,and be used as the markers for estimating the degree of differentiation of floor-of-mouth squamous cancer.