Analysis on risk factors of neuron-specific enolase increasing in patients with cerebral ischemic stroke / 中国医师进修杂志

ABSTRACT

Objective To investigate the risk factors of neuron-specific enolase (NSE) increasing in patients with cerebral ischemic stroke (CIS) by Logistic regression analysis,in order to provide the more theoretical basis for the prevention and treatment of the CIS.Methods A total of 210 patients with CIS from May 2007 to December 2011 was enrolled in this study.The neurological dysfunction was evaluated by U.S.National Institutes of Health Stroke Scale (NIHSS).The carotid artery intima-media thickness(IMT)was assessed by ultrasonography.The level of serum NSE was measured by ECLIA analysis.The patients were divided into low NSE group (NSE ≤12 μ g/L) and high NSE group (NSE ＞ 12 μ g/L).Results Low NSE group had 94 cases,and high NSE group had 116 cases.Univariate analysis showed that there was significant difference in NIHSS score,carotid artery IMT,hypertension,coronary heart disease,diabetes,white blood cell count,total cholesterol (TC),triacylglycerol (TG),low-density lipoprotein cholesterol (LDL-C) and high-density lipoprotein cholesterol (HDL-C) between low NSE group and high NSE group [(15.8 ± 3.4) scores vs.(21.6 ± 4.7) scores,(1.12 ± 0.31) mm vs.(1.68 ± 0.54) mm,29.8％(28/94) vs.58.6％(68/116),17.0％(16/94) vs.30.2％(35/116),13.8％(13/94) vs.27.6％(32/116),(6.68 ± 3.45) ×109/L vs.(10.08 ± 4.27) × 109/L,(4.67 ± 1.22) mmol/L vs.(5.01 ± 1.64) mmol/L,(1.26 ± 0.44) mmol/L vs.(1.74 ±0.61) mmol/L,(3.42 ± 1.14) mmol/L vs.(5.26 ± 1.64) mmol/L,(1.32 ±0.22) mmol/L vs.(1.01 ± 0.17) mmol/L](P ＜ 0.05).Logistic regression analysis showed that NIHSS score,carotid artery IMT,white blood cell count,LDL-C,hypertension and diabetes were the independent risk factors of NSE increasing in patients with CIS.Conclusions NIHSS score,carotid artery IMT,white blood cell count,LDL-C,hypertension,diabetes are the independent risk factors of NSE increasing in patients with CIS.Treatment on the related risk factors can be expected to reduce the incidence of CIS,relieve the condition of disease and improve the prognosis of CIS.