Expressions and significances of microRNA-21, PTEN, NF-κB and caspase-9 in colon carcinoma / 中国医师杂志
Journal of Chinese Physician
;
(12): 39-41, 2013.
Article
in Chinese
| WPRIM
| ID: wpr-432874
ABSTRACT
Objective To investigate expressions of microRNA-21 (miR-21),PTEN,NF-κB,and caspase-9 in colon carcinoma and their possible mechanisms in progression of tumor.Methods Expressions of above-mentioned indexes and percentage of apoptotic cells in colon carcinoma,colon adenoma,and normal tissue specimen were detected.Results Expressions of miR-21,PTEN,N F-κB,and caspase9 in normal tissue were 0.39 ±0.02,50%,25%,and 50%.Expressions of them in colon adenoma were 0.62 ±0.06,50%,35%,and 55%,and those in colon carcinoma were 0.88 ±0.04,30%,75%,and 20%.Percentage of apoptotic cells were (24.64 ± 7.66) %,(15.86 ± 1.44) %,and (6.20 ± 2.57) %,respectively.The above P-values were all less than 0.05.Expression of miR-21 was positively correlated with TNM stage,depth of infiltration,differentiated level and expression of NF-κB while inversely correlated with PTEN and caspase-9 expressions and percentage of apoptotic cells.The r-values were 0.647,0.297,0.259,0.519,-0.299,-0.388,and-0.931,respectively.Conclusions Hyperexpression of miR-21 participated in progression of colon carcinoma probably through down-regulating expressions of PTEN and caspase-9 and up-regulating expression of NF-κB and then suppressing cell apoptosis.
Full text:
Available
Index:
WPRIM (Western Pacific)
Language:
Chinese
Journal:
Journal of Chinese Physician
Year:
2013
Type:
Article
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