GluR2 expression in the developing rat inferior colliculus and the relationship with development of synapse / 临床耳鼻咽喉头颈外科杂志

ABSTRACT

Objective:To observe the GluR2 expression in rat inferior colliculus (IC) in different developmental stages , and to investigate its developmental change and relationship with the synapse development.Method: The expression of GluR2 and synaptophysin(SYP) in IC were detected by double immunofluorescence method.Result:①All sorts of neurons in IC expressed GluR2 in every postnatal groups, and the GluR2 expression in P6w groups was higher than that in other groups .②The expression of GluR2 were different in different subnucleus of IC.③All sorts of neurons in IC expressed SYP in every postnatal groups, and the SYP expression in P6w groups was higher than others. ④The expressions of GluR2 consistented with the expression of SYP in IC.Conclusion:The developmental changes of GluR2 and SYP expression in the rat IC may be involved in the development and plasticity of auditory center.