Relationship between Serum Cystatin C and Arterial Stiffness in Type 2 Diabetes Patients with Normal Renal Function
Soonchunhyang Medical Science
;
: 21-25, 2012.
Article
in Korean
| WPRIM
| ID: wpr-43365
ABSTRACT
OBJECTIVE:
Several studies showed that increased arterial stiffness is an independent risk factor for cardiovascular disease. Pulse wave velocity (PWV) is known as a marker for large vessel stiffness. Recent studies show that serum cystatin C is associated with PWV and may predict future cardiovascular events, even in subjects with normal renal function. However, there have been few studies for the relationship between cystatin C and arterial stiffness in patients with type 2 diabetes (T2DM). In this study, we investigated the relationship between serum cystatin C and branchial-ankle PWV in T2DM patients with normal renal function.METHODS:
Patients with urinary albumin/creatinine ratio (ACR) higher than 300 microg albumin/mg creatinine, estimated glomerular filtration rate (eGFR) less than 60 mL/min were excluded. A total of 88 patients (47 male/41 female; age, 59+/-2 years; ACR, 33+/-5 microg/mg) were included. Doppler-derived aortic PWV and serum cystatin C were measured.RESULTS:
Cystatin C is significantly related to age (r=0.51, P<0.001), hemoglobin A1c (r=-0.23, P<0.05), high density lipoprotein-cholesterol (r=-0.22, P<0.05), apoprotein A (r=-0.22, P<0.05), and eGFR (r=-0.56, P<0.001). Aortic PWV is significantly associated with age (r=0.29, P<0.01), cystatin C (r=0.33, P<0.005), and eGFR (r=-0.24, P<0.05). In multiple regression analysis, there is significant association between aortic PWV and serum cystatin C levels.CONCLUSION:
Serum cystatin C is significantly associated with arterial stiffness in T2DM patients with normal renal function. Our results suggest that cystatin C could be a marker for early atherosclerosis in T2DM patients.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Apoproteins
/
Hemoglobins
/
Cardiovascular Diseases
/
Risk Factors
/
Creatinine
/
Diabetes Mellitus, Type 2
/
Atherosclerosis
/
Cystatin C
/
Vascular Stiffness
/
Pulse Wave Analysis
Type of study:
Etiology study
/
Prognostic study
/
Risk factors
Limits:
Humans
Language:
Korean
Journal:
Soonchunhyang Medical Science
Year:
2012
Type:
Article
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