Pharmacokinetic study of perlolyrine in rats by means of stable isotope dilution / 中国药学杂志
Chinese Pharmaceutical Journal
; (24): 45-47, 2001.
Article
in Zh
| WPRIM
| ID: wpr-433787
Responsible library:
WPRO
ABSTRACT
OBJECTIVE To determine the pharmacokinetic parameters of perlolyrine in rats.METHODS The plasma concentration and pharmacokinetic parameters of perlolyrine were determined by means of GC-MS with selected ion (m/z 247 and m/z 248) and [2-15N]perlolyrine(m/z 248) as the internal standard.RESULTS The concentration-time profile of perlolyrine after oral administration of perlolyrine fitted a two-compartment open model.The pharmacokinetic parameters were t1/2α=0.31 h, t1/2β=4.62 h, t1/2ka=0.10 h, tmax=0.34 h, cmax=18.74 ng.mL-1,K12=0.82 h-1, K21=0.38h-1,K10=0.29 h-1,Vb=108.16 L.kg-1,AUC=98.54 ng.h.mL-1,respectively.CONCLUSION The method is constant,sensitive and accurate.It provided a scientific basis for the clinical use of perlolyrine.
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WPRIM
Language:
Zh
Journal:
Chinese Pharmaceutical Journal
Year:
2001
Type:
Article