Pharmacokinetic study of bifonazole in human / 中国药学杂志
Chinese Pharmaceutical Journal
;
(24): 43-45, 2001.
Article
in Chinese
| WPRIM
| ID: wpr-433788
ABSTRACT
OBJECTIVE To study the pharmacokinetics of bifonazole in healthy human,in order to evaluate the safety of bifonazole.METHODS 8 healthy volunteers were given single dose of 300 mg bifonazole solution and cream preparation respectively in a cross-over design.Blood samples were collected at the designed time,and the concentrations of bifonazole in plasma were determined by means of GC-MS(SIM) quantitative method.The pharmacokinetic parameters were calculated with the 3P87 software.RESULTS The plasma concentration-time curves of the two preparations were fitted to two-compartment open model.The tmax of the solution and cream preparations were 2.91 h and 5.62 h,cmax 713.46 ng.mL-1 and 410.70 ng*mL-1,respectively.The cream preparations absorption,distribution and clearance was a little slower than that of the solution preparation.However,no significant difference in their AUC.CONCLUSION Bifonazole is a safe drug,and clinical use of the solution and cream preparation in turn is suggested to improve its therapeutic efficacy.
Full text:
Available
Index:
WPRIM (Western Pacific)
Type of study:
Controlled clinical trial
Language:
Chinese
Journal:
Chinese Pharmaceutical Journal
Year:
2001
Type:
Article
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