The study of TNF-α destructive action to the bone in human middle cholesteatoma / 临床耳鼻咽喉头颈外科杂志
Journal of Clinical Otorhinolaryngology Head and Neck Surgery
;
(24): 13-14, 2001.
Article
in Chinese
| WPRIM
| ID: wpr-433830
ABSTRACT
Objective:
To study the expression of TNF-α in the cholesteatoma and elucidate the role of TNF-α in the destruction of bone.Method:
All samples (5 μm paraffin sections) from 25 cholesteatoma cases and 10 normal cases were examined by immunohistochemical SABC method and analysed by computer image.Result:
In 25 cholesteatoma cases,TNF-α expressed in the cytoplasm of the full epithelial tissue cells,subcutaneous inflammatory cells and fibroblast.In contrast,the normal cases,there were 6 cases week positive,4 cases negative.The results of the computer image quantitative analysis system showed that the mean optical density of TNF-α was 0.1326±0.0022 in the cholesteatoma epithelial tissue and 0.0868±0.0014 in normal skin epithelial tissue respectively,both of which had significantly differentiation (P<0.05).Conclusion:
TNF-α may be a factor of the destruction of bone of cholesteatoma.
Full text:
Available
Index:
WPRIM (Western Pacific)
Language:
Chinese
Journal:
Journal of Clinical Otorhinolaryngology Head and Neck Surgery
Year:
2001
Type:
Article
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