The Relationship between the Bcl-2/Bax Ratio and Drug Resistance in Acute Myelogenous Leukemia / 医药导报
Herald of Medicine
;
(12): 87-88, 2001.
Article
in Chinese
| WPRIM
| ID: wpr-433874
ABSTRACT
Objective:
To investigate Bcl-2 and Bax gene expression in acute myelogenous Leukemia and the relationship between Bcl-2/Bax ratio and drug resistance.Method:
Expression of Bcl-2、Bax was detected by immunohistochemical method while drug resistance of AML was detected by cell culture and MTT assay.Results:
A high expression of Bcl-2 and a low expression of Bax were detected in AML,respectively,and the ratio between Bcl-2 and Bax was significantly higher than that in normal control (P<0.01). The ratio in those who are resistant to chemotherapy was significantly higher than that in those sensitive to chemotherapy (P<0.05).The responsiveness to chemotherapy of those with a high ratio was poorer than thos with a low ratio (P<0.05).Conclusion:
The alteration of Bcl-2 and Bax played certain role in the development of drug resistance in AML,the test of Bcl-2/Bax ratio may have great significance in choice of chemotherapeutic agents and also provide important information for outcome prediction.
Full text:
Available
Index:
WPRIM (Western Pacific)
Type of study:
Prognostic study
Language:
Chinese
Journal:
Herald of Medicine
Year:
2001
Type:
Article
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