Study on the correlation of alpha fetoprotein half-life and relapse or metastasis of primary hepatocellular carcinoma / 免疫学杂志
Immunological Journal
;
(12): 135-137, 2001.
Article
in Chinese
| WPRIM
| ID: wpr-433883
ABSTRACT
Objective To clarify the correlation of alpha fetoprotein (AFP) half-life (T1/2) with relapse or/and metastasis of primary hepatocellular carcinoma (PHC) after treatment. Methods Determination of AFP content in serum with two steps double McAb sandwich ELISA.Calculation AFP T1/2 of the sufferers treated with intervention and radiofrequency ablation (RFA) according to T1/2=0.3 dT/log(AFP1/AFP2). Results When AFP T1/2>11.5 days, the sensitivity, specificity and accuracy of predicting the relapse or metastasis of PHC after treatment were 87.5%, 89.3%, 88.5%, respectively. Intervention group was 82.35%, 83.3%, 82.75%, respectively and RFA group was 93.3%, 93.75%, 93.5%, respectively. During 200 days,there was very significant difference of AFP T1/2 (P<0.001) between non-relapsed/ non-metastasized and relapsed, metastasized and died. Conclusions AFP T1/2 can be used as a predictive index for relapse, metastasis of PHC after treatment. It is not only a reliable parameter for the later stage treatment, but also a useful index for the evaluation of effect.
Full text:
Available
Index:
WPRIM (Western Pacific)
Language:
Chinese
Journal:
Immunological Journal
Year:
2001
Type:
Article
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