Clinical significance of urinary IL-8 in patients with lupus nephritis / 免疫学杂志
Immunological Journal
;
(12): 123-124, 2001.
Article
in Chinese
| WPRIM
| ID: wpr-433885
ABSTRACT
Objective To evaluate the clinical value of detection of urinary interleukin-8(IL-8) in patients with lupus nephritis (LN).Methods Urinary levels of IL-8 were determined by using sandwich ELISA in 38 LN patients.Results In the LN patients during the stage of normal renal function and diminished renal reserve stage, urinary levels of IL-8 were significantly higher than those in healthy controls(P<0.001),and urinary levels of IL-8 in the patients during diminished renal reserve stage were significantly higher than those in the patients during normal renal function stage(P<0.01).High IL-8 levels in LN patients were associated with high levels of erythrocyte sedimentation rate and lower levels of C3 complement components. Urinary levels of IL-8 in LN patients with microscopic leukocyturia were significantly higher than those without microscopic leukocyturia. In LN patients treated with cyclophosphamide (CTX) and prednisone, urinary IL-8 levels of post-treatment were significantly lower than those of pre-treatment(P<0.01). Conclusions Urinary levels of IL-8 may be a useful indicator for monitoring disease activity and degree of renal damage in LN. The mechanism of noninfective leukocyturia may be associated with the elevation of urinary IL-8 levels in LN. CTX and prednisone may have a significant effect on inhibiting the production of IL-8 in the immunocytes and renal intrinsic cells.
Full text:
Available
Index:
WPRIM (Western Pacific)
Language:
Chinese
Journal:
Immunological Journal
Year:
2001
Type:
Article
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