Expression and significance of TGF-β1 in nasal polyps / 临床耳鼻咽喉头颈外科杂志
Journal of Clinical Otorhinolaryngology Head and Neck Surgery
;
(24): 206-208, 2001.
Article
in Chinese
| WPRIM
| ID: wpr-434025
ABSTRACT
Objective:
To study the expression and significance of transforming growth factor-β1 (TGF-β1) in nasal polyps.Method:
Expression of TGF-β1 in nasal polyps from 34 patients and middle turbinates from 30 patients with deviation of nasal septum were prospectively studied with immunohistochemistry.Each tissue section was observed under optical microscope.Result:
①The TGF-β1 positivity in extracellular matrix and in cells in the stroma was significantly higher in nasal polyps than in middle turbinates (P<0.01).②The distribution and shape of TGF-β1 expressing cells in nasal polyps was similar to that of eosinophil,their positivities were significantly correlative (P<0.05).③The positivity of TGF-β1 did not correlate with clinical type of nasal polyps (P>0.05),eosinophil infiltration correlated significantly with clinical type of nasal polyps(P<0.05).Conclusion:
①The TGF-β1 may contribute to some of the pathologic changes observed in nasal polyps,such as thickening of the epithelial basement membrane and stromal fibrosis.②Eosinophils in nasal polyps represent a major source of TGF-β1.③Eosinophils infiltration may play a prominent role in the development and recurrence of nasal polyps.
Full text:
Available
Index:
WPRIM (Western Pacific)
Language:
Chinese
Journal:
Journal of Clinical Otorhinolaryngology Head and Neck Surgery
Year:
2001
Type:
Article
Similar
MEDLINE
...
LILACS
LIS