Total Asymmetric Synthesis of 3'R,4'R-Disubstituted Angular Dihydropyranocoumarins / 中国药科大学学报
Journal of China Pharmaceutical University
;
(6): 205-209, 2005.
Article
in Chinese
| WPRIM
| ID: wpr-434050
ABSTRACT
AIM:
To obtain new typical compounds with dual mechanism,antagonizing Ca2+and inhibiting acetylcholinesterase,on Alzheimer's disease.METHODS:
Resorcinol was chosen as primitive substrate,and AD-mix-β as asymmetrically dihydroxylated reagent;all products were screened against acetylcholinesterase in vitro.RESULTS:
cis-3′R,4′R-disubstituted angular dihydropyranocoumarins were synthesized enantioselectively,however,its inhibitory activity on acetylcholinesterase is distinctively lower than that of cis-3′R,4′R-disubstituted linear dihydropyranocoumarins.
Full text:
Available
Index:
WPRIM (Western Pacific)
Language:
Chinese
Journal:
Journal of China Pharmaceutical University
Year:
2005
Type:
Article
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