Expression of aldehyde dehydrogenase 1 in breast cancer and its clinical significance / 肿瘤
Tumor
;
(12): 663-667, 2009.
Article
in Chinese
| WPRIM
| ID: wpr-434190
ABSTRACT
Objective:
The purpose of this study is to investigate the expression of tumor stem cell marker aldehyde dehydrogE-nase 1 (ALDH1) in breast cancer and its clinical significance.Methods:
The expression of ALDH1 protein was examined by immunohistochemical staining in 92 breast cancer tissues. The correlation analysis and diseasE-free survival analysis of patients was evaluated based on the clinical follow-up data.Results:
Expression of ALDH1 protein had a significant correlation with progesterone receptor (PR) and cerb-B2 (P0.05). The 2-year diseasE-free survival rate of AlDH1-positive patients was lower than that of ALDH1-negative patients (P<0.05). ALDH1-positive patients, who received CEF regimen chemotherapy and hormone therapy, had lower 2-year diseasE-free survival rate than that of ALDH1-negative patients (P<0.05).Conclusion:
The decreased diseasE-free survival rate of ALDH1-positive patients is related with drug resistance. ALDH1 could be used as an independent factor for predicting the prognosis of breast cancer.
Full text:
Available
Index:
WPRIM (Western Pacific)
Type of study:
Prognostic study
Language:
Chinese
Journal:
Tumor
Year:
2009
Type:
Article
Similar
MEDLINE
...
LILACS
LIS