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Expression of aldehyde dehydrogenase 1 in breast cancer and its clinical significance / 肿瘤
Tumor ; (12): 663-667, 2009.
Article in Chinese | WPRIM | ID: wpr-434190
ABSTRACT

Objective:

The purpose of this study is to investigate the expression of tumor stem cell marker aldehyde dehydrogE-nase 1 (ALDH1) in breast cancer and its clinical significance.

Methods:

The expression of ALDH1 protein was examined by immunohistochemical staining in 92 breast cancer tissues. The correlation analysis and diseasE-free survival analysis of patients was evaluated based on the clinical follow-up data.

Results:

Expression of ALDH1 protein had a significant correlation with progesterone receptor (PR) and cerb-B2 (P0.05). The 2-year diseasE-free survival rate of AlDH1-positive patients was lower than that of ALDH1-negative patients (P<0.05). ALDH1-positive patients, who received CEF regimen chemotherapy and hormone therapy, had lower 2-year diseasE-free survival rate than that of ALDH1-negative patients (P<0.05).

Conclusion:

The decreased diseasE-free survival rate of ALDH1-positive patients is related with drug resistance. ALDH1 could be used as an independent factor for predicting the prognosis of breast cancer.

Full text: Available Index: WPRIM (Western Pacific) Type of study: Prognostic study Language: Chinese Journal: Tumor Year: 2009 Type: Article

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Full text: Available Index: WPRIM (Western Pacific) Type of study: Prognostic study Language: Chinese Journal: Tumor Year: 2009 Type: Article