Clinical Literature Analysis of Influence on Si-shen Decoction on Biological Markers of Knee Osteoarthritis / 世界科学技术-中医药现代化

ABSTRACT

This study was aimed to analyze the domestic relevant documents since 1991 involving Si-shen Decoc-tion and its individual component drugs with knee osteoarthritis biomarkers. This article took medical journal databases of CBMdisc, CNKI, SWIC and Wanfang as sources of information, and searched respectively with key words such as knee osteoarthritis and biomarkers, Si-shen Decoction or Leguminosae, Dendrobium,Achyranthes bidentata, Polygala tenuifolia Willd, Lonicera Japonica and biomarkers such as matrix metalloproteinase, cartilage oligomeric matrix protein, collagen type II C-telopeptide. Bibliometric analysis was given on the acquired relevant documents. The results showed that among 340 documents about knee os-teoarthritis and biomarkers, IL-1, TNF-α and MMPs are mostly used to respond the index of cartilage degenera-tion. Among 565 documents about Si-shen Decoction and its individual component drugs with biomarkers, they are mostly concentrated on the index of TNF-α, IL-1 and oxygen free radical, and the research methods are relatively mature. It was concluded that the bibliometrics method has certain significance in the effect of Si-shen Decoction in the treatment of knee osteoarthritis. More study is required to provide evidence in the development of Si-shen Decoction into a specific prescription for the treatment of knee osteoarthritis.