Prevention of chronic graft-versus-host disease by stimulation with glucocorticoid-induced TNF receptor
Experimental & Molecular Medicine
;
: 94-99, 2006.
Article
in English
| WPRIM
| ID: wpr-43450
ABSTRACT
GITR (glucocorticoid-induced TNF receptor) is a recently identified member of the TNF receptor superfamily. The receptor is preferentially expressed on CD4+CD25+ regulatory T cells and GITR signals break the suppressive activity of the subset. In this study, we wanted to reveal the in vivo function of GITR in chronic graft-versus-host disease (cGVHD), a lupus-like autoimmune disease. A single injection of anti-GITR monoclonal antibody (DTA-1) was effective in blocking the progression of cGVHD in the parent-into-F1 model. Treatment of DTA-1 significantly decreased levels of IgG1 anti-DNA autoantibody, inhibited glomerulonephritis, and increased survival. The DTA-1-mediated inhibition of autoantibody production correlated with deletion of B cells and could occur independently of CD4+CD25+ regulatory T cells. Our results indicate that anti-GITR monoclonal antibody may be used as a potential immunotherapeutic agent for preventing cGVHD.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Transplantation, Homologous
/
Enzyme-Linked Immunosorbent Assay
/
Comparative Study
/
B-Lymphocytes
/
CD4-Positive T-Lymphocytes
/
Fluorescein-5-isothiocyanate
/
Receptors, Tumor Necrosis Factor
/
Microscopy, Confocal
/
Fluorescent Antibody Technique, Indirect
/
Flow Cytometry
Type of study:
Prognostic study
Limits:
Animals
Language:
English
Journal:
Experimental & Molecular Medicine
Year:
2006
Type:
Article
Similar
MEDLINE
...
LILACS
LIS