Comparison on the therapeutic efficacies of endoscopic submucosal dissection and surgical operation treatment of early gastrointestinal cancers / 中国医师杂志

ABSTRACT

Objective To compare the therapeutic efficacies of endoscopic submucosal dissection and surgical operation treatment of early gastrointestinal cancers.Methods Sixty patients with early gastrointestinal cancer were divided into the endoscopic submucosal dissection (ESD) treatment group (n =33patients) and surgical operation treatment group (n =27 patients).During the treatment,success rate,survival time,recurrence and metastasis,nutritional status,adverse reaction and complication rate,hospital stay,and cost of treatment were observed for two groups.Results No statistical significances in success rate,survival time,recurrence and metastasis were found between two groups (P ＞ 0.05).The rate of normal nutritional status value was 90.9％ (30/33) in group ESD and 66.7％ (18/27) in the surgical group with a statistically significant difference between two groups (P ＜ 0.05).The rate of adverse reaction and complication was 9.09％ (3/33) in group ESD and 59.2％ (16/27) in the surgical group with a statistically significant difference between two groups (P ＜ 0.05,P ＜ 0.01).The average length of stay (14,81 ± 3.27) days and the average hospitalization expenses (10562.01 ± 3060.08) Yuan were occurred in the group ESD.The average length of hospital stay (19.22 ± 6.91)days and the average hospitalization expenses (16587.87 ±5664.50)Yuan were occurred in the surgical group.The average length of hospital stay in surgical group was longer 4,41 days than group ESD.The average hospitalization expense in surgical group was 6025.86 yuan more than the ESD group.Conclusions The curative effects of ESD treatment was similar to surgical operation,and there was a lower postoperative adverse reaction rate,a shorter time of hospitalization,a relatively low cost of treatment for ESD treatment compared to the surgical operation.Moreover,ESD treatment can especially keep the gastrointestinal integrity for patients,and the life quality rises significantly.