Correlation between asymmetric dimethylarginine and endothelial dysfunction in patients with uremia / 中国医师杂志

ABSTRACT

Objective To investigate the correlation between asymmetric dimethylarginine (AD-MA) and endothelial dysfunction in patients with uremia.Methods Uremic patients who did not receive hemodialysis were defined as A group (n =40) ; uremic patients who had received hemodialysis were divided into B group (n =45) ;healthy people were defined as C group (n =20) ;and chronic kidney disease (stage 2 ～ 4) patients were defined as D group (n =20).The diameter of intima-media thickness,and endothelium-dependent or independent dilation (EDD or EID) of radial artery in right forearm were detected with diasonography.The levels of ADMA were determined by high-performance liquid chromatography.Results Compared to C group,the levels of ADMA in A,B and D groups were significantly increased [C(0.78 ±0.19) μmol/L,A(1.51 ±0.16) μ mol/L,B(1.13 ±0.14) μmol/L,D(0.92 ±0.11) μmol/L; P ＜0.05].Compared to A group,the levels of ADMA were significantly decreased in B group (P ＜0.05).EDD and EID were decreased significantly in A,B and D groups compared to C group [EDDC(13.52±1.73)％ vs A(7.32 ±0.54)％,B(9.02 ±0.86)％,D(10.13 ±1.25)％,P ＜0.05;EIDC(14.45±1.85)％ vsA(10.37 ±1.51)％,B(9.54±1.39)％,D(11.17±1.56)％,P ＜0.05].EDD in B group was significantly lower than A group (P ＜0.05).In group A,a negative correlation was found between EDD and the level of ADMA (r =-0.81,P =0.020).Conclusions ADMA level was significantly increased in uremic patients.A close correlation existed between ADMA and endothelial dysfunction of radial artery.