Relationship of serum thyroid stimulating hormone level with differentiated thyroid cancer / 中华内分泌代谢杂志

ABSTRACT

Objective To investigate the association between preoperative serum TSH level and differentiated thyroid cancer (DTC).Methods The relationship between TSH concentration and differentiated thyroid cancer in 400 qualified patients with thyroid nodules was retrospectively analyzed from January 2009 to December2011 in our hospital.Based on the TSH values,the patients were divided into five groups.Results Preoperative serum TSH level in DTC group was higher than that in benign thyroid nodales group [(2.94 ± 1.74 vs1.92 ± 1.45) μ IU/ml,P＜0.01].The risk of DTC increased as serum level of TSH rose in the patients with thyroid nodule.The incidences of DTC were 27.8％,34.0％,40.0％,63.4％,and 70.2％ respectively in groups with TSH＜0.27,0.27-1.44,1.45-2.19,2.20-4.20,and ＞4.20 μIU/ml groups.TSH level in the group with cervical lymph node metastasis was higher than that without metastasis (P＜0.01).Conclusions The likelihood of thyroid cancer increases with increased serum TSH concentration.High TSH level seems to be associated with lymph node metastasis.Preoperative serum TSH level might be a risk predictor for DTC.