Clinical efficacy of sulfonic acid L-amlodipine and its influence on vascular endothelial function in treatment of primary hypertension / 中国医师进修杂志

ABSTRACT

Objective To observe the clinical efficacy of sulfonic acid L-amlodipine and its influence on vascular endothelial function in treatment of primary hypertension.Methods Two hundred primary hypertension patients(hypertension group) were divided into amlodipine group and telmisartan group by random digits table method with 100 cases each.The patients of amlodipine group were given the sulfonic acid L-amlodipine treatment,while the patients of telmisartan group were given the telmisartan treatment.The change of systolic blood pressure (SBP),diastolic blood pressure(DBP),nitric oxide (NO),endothelin (ET)-1 and blood lipid before and after treatment,and the adverse reaction were observed continuously for 4 weeks.Also 80 cases of healthy people (control group) were included as a comparative study.ResultsBefore treatment,the lipid levels,blood pressure,NO,ET-1 of hypertension group showed significant difference compared with those of control group (P ＜0.05).The effective rate of amlodipine group and telmisartan group was 97.0％(97/100) and 88.0％(88/100) respectively,and there was significant difference between two groups (x2 =5.838,P ＜ 0.05).After treatment,DBP and SBP of amlodipine group and telmisartan group significantly improved,the difference was significant compared with that before treatment [(77.93 ±24.74) mm Hg (1 mm Hg =0.133 kPa) vs.(103.37 ±34.46) mm Hg,(113.83 ±36.14) mm Hg vs.(167.74 ± 55.91) mm Hg and (85.93 ± 27.28) mm Hg vs.(104.23 ± 34.74) mm Hg,(135.93 ± 43.15)mm Hg vs.(164.57 ±54.86) mm Hg] (P ＜0.05).The blood pressure of amlodipine group meliorated more significantly,and the difference was significant compared with that of telmisartan group (P ＜ 0.05).NO and ET-1 of amlodipine group basically reached normal levels,and the difference was significantly compared with that of telmisartan group [(70.28 ±22.31) μmol/L vs.(50.97 ± 16.99) μmol/L,(60.93 ± 19.34)μ mol/L vs.(51.15 ± 17.05) μ mol/L and (52.69 ± 16.73) ng/L vs.(69.38 ± 23.13) ng/L,(65.71 ± 20.86)ng/L vs.(71.58 ± 23.86) ng/L] (P ＜ 0.05).The adverse reaction was not observed during treatment.Conclusions The clinical efficacy of sulfonic acid L-amlodipine on vascular endothelial function in treatment of primary hypertension is obvious and safe,which could improve the endothelial dysfunction.So this method is worthy of popularizing.