BDNF and TrkB may be new hope for treatment of tumor / 国际外科学杂志
International Journal of Surgery
;
(12): 389-394, 2013.
Article
in Chinese
| WPRIM
| ID: wpr-435306
ABSTRACT
Brain-derived neurotrophic factor is the ligands of tyrosine kinase receptor B,for the binding of brain-derived neurotrophic factor to tyrosine kinase receptor B receptor,signal transmitted to the nucleus,resulting in a variety of biological effects.Lots of researchs had found that brain-derived neurotrophic factor and tyrosine kinase receptor B expression in malignant tumors more than non-cancerous adjacent tissue and normal tissue,and their effect can promote tumor blood vessel formation,suppress of cell anoikis,promote tumor growth,differentiation and metastasis.The relationship of brain-derived neurotrophic factor and tyrosine kinase receptor B provide a new therapeutic strategy for clinical treatment.From the current basic and clinical research,this treatment strategy has great prospect.
Full text:
Available
Index:
WPRIM (Western Pacific)
Language:
Chinese
Journal:
International Journal of Surgery
Year:
2013
Type:
Article
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