Long noncoding RNA in digestive system neoplasms / 中国肿瘤临床
Chinese Journal of Clinical Oncology
;
(24): 938-940, 2013.
Article
in Chinese
| WPRIM
| ID: wpr-435654
ABSTRACT
Long noncoding RNA (lncRNA) comprises a group of RNAs that are longer than 200 nucleotides. The lncRNA does not contain functional open reading frames and cannot encode proteins. RNA accounts for a large proportion in the total noncoding RNAs. The number, type, and function of lncRNA are unclear, so they have been called the dark matter of the genome. With the applica-tion of a new generation of gene sequencing technology, lncRNA is found to be involved in the mechanisms mediating the signal trans-duction pathway, regulating the cell cycle, and inducing cell apoptosis. In this article, the authors summarized the up-to-date research progress on lncRNA in digestive system neoplasms in China and overseas to provide new insights into the genetic diagnosis and treat-ment of digestive system neoplasms in clinics.
Full text:
Available
Index:
WPRIM (Western Pacific)
Language:
Chinese
Journal:
Chinese Journal of Clinical Oncology
Year:
2013
Type:
Article
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