Analysis of 76 adverse reactions reports of gatifloxacin injection / 中国基层医药

ABSTRACT

Objective To find out the clinical adverse reactions of gatifloxacin injection,to analyze its influencing factors,and provide reference data for the clinical use of the drug.Methods 76 gatifloxacin adverse reaction reports were collected in our hospital.The patients' gender,age,time of the occurrence of adverse reaction,classification of clinical manifestations,the joint drug use,treatment methods and outcome were analyzed.The causalities of adverse reactions were analyzed.Results Adverse reactions of gatifloxacin in most patients occurred less than 1 day,accounting for 90.79％.83 adverse performances occurred in the 76 cases of adverse reactions,the most common adverse reactions occurred in digestive system,accounting for 40.96％ ;followed by cutaneous adverse reactions 15 cases,accounting for 18.07％ ;systemic adverse reactions 8 cases,accounting for 9.64％.Gatifloxacin combined with other drugs in 59 cases,accounting for 77.63％.45 cases combined with antibacterial drugs,including penicillin,fosfomycin,azithromycin,cefepime,ceftizoxime,amoxicillin-sulbactam,etc..In 76 cases of adverse reactions,13 caseswere definitely related,accounting for 17.11％ ;45 cases were likely to be relevant,accounting for 59.21％ ; 17cases were may be relevant,accounting for 22.37％ ;1 case wasto be evaluated,accounting for 1.32％ ;0 casewas could not be evaluated.Conclusion The adverse reactions monitoring of gatifloxacin injection must be strengthened,the prospective re-evaluation should be made,so that the adverse reactions can be reduced.