Relationship between level of inflammatory factors and carotid intima-media thickness in patients with type 2 diabetes mellitus / 中国综合临床

ABSTRACT

Objective To explore the relationship between the levels of inflammatory factors and carotid intima-media thickness (IMT) in patients with type 2 diabetes mellitus (T2DM).Methods Fifty patients with T2DM were recruited and divided into T2DM with insulin resistance(IR) group(26 patients) and T2DM without insulin resistance (NIR) group (24 patients) according to insulin resistance index (HOMA-IR).Twenty-four healthy individuals conducting physical examination were recruited as the healthy control group.All participants underwent carotid ultrasound IMT to assess carotid intima-media thickness.The level of fasting plasma glucose (FPG),fasting insulin (FINS),blood lipids,high sensitivity C reactive protein (hs-CRP) and tumor necrosis factor-α(TNF-α) were measured.Homeostasis model assessment (HOMA)index was used for quantitative analysis of HOMA-IR.Results The levels of HOMA-IR,hs-CRP,TNF-α and IMT in control group,NIR group and IR group increased gradually and were significantly different(HOMA-IR(1.74 ±0.49) vs.(2.24 ±0.41) vs.(4.89 ±0.84) ;F =190.228,P ＜0.01) ;hs-CRP(mg/L)(1.75 ±0.83) vs.(3.08 ± 1.04) vs.(5.89 ± 1.17) ;F =106.523,P ＜ 0.01) ;TNF-α (ng/L)(15.25 ± 7.64) vs.(23.38 ± 8.82) vs.(47.42 ± 9.97) ;F =89.210,P＜0.01) ;IMT(mm)(0.69 ±0.31) vs.(1.07±0.32) vs.(1.49±0.43);F=30.942,P＜0.01).Correlation analysis showed that the level of hs-CRP was positively correlated with the levels of HOMA-IR and IMT (r =0.453 and 0.395 respectively,P ＜ 0.05) ;The level of TNF-α was positively correlated with the levels of HOMA-IR and IMT (r =0.428 and 0.376 respectively,P ＜ 0.05) ; The level of HOMA-IR was positively correlated with the level of IMT (r =0.403,P ＜ 0.05).Conclusion Inflammatory activity is found in patients with T2DM,which is significantly correlated with insulin resistance.Inflammatory factors and insulin resistance play an important role in the occurrence and development of carotid atherosclerosis in patients with T2DM.