Distribution of HLA-C alleles in Shandong Han population of China / 中华微生物学和免疫学杂志
Chinese Journal of Microbiology and Immunology
;
(12): 330-333, 2013.
Article
in Chinese
| WPRIM
| ID: wpr-436507
ABSTRACT
Objective To analyze the distribution of HLA-C alleles in Shandong Han population of China.Methods One hundred and fifty unrelated potential donors,self-claimed as Han population from Shandong province,were selected from China Marrow Donor Program.Genotypes of HLA-C with the donors were identified by PCR-SBT.The frequencies of allele were calculated with direct counting method and the differences with other populations were analyzed with SPSS16.0 x2 software.Results A total of 25 alleles of HLA-C were observed and the most common alleles were C * 0602 and C * 0702 with the frequency of more than 10.00%.Moreover,there were 16 kinds of alleles with the frequency of more than 1.00% accounting for 95.33% of the total alleles.The distribution of HLA-C alleles in Shandong Han population was similar to that in northern Han population,but had some differences with that in southern Han population.In addition,the distribution of HLA-C alleles in Shandong Han population significantly differed from that of German/African American.Conclusion This study on the distribution of HLA-C alleles in Shandong Han population provides valuable references for further studies on the genetics of HLA,cross-match for organ transplantation and other genetic-associated diseases in this population.
Full text:
Available
Index:
WPRIM (Western Pacific)
Language:
Chinese
Journal:
Chinese Journal of Microbiology and Immunology
Year:
2013
Type:
Article
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