The clinical analysis of anti-infection treatment after 492 cases of orthopedics operation / 中国基层医药

ABSTRACT

Objective To investigate the effect after operation infection in the department of orthopedics in our hospital,and to explore the use of antibiotics to prevent infection treatment best administration time,duration of drugs and the effect of several drug combination therapy.Methods 492 patients were randomly divided into A,B,C groups,A group included 163 cases in β-lactam and Aminoglycosides,B group was 162 cases in β-lactam and Macrolide,C group 167 cases were in two β-lactam.Comparison of three groups of anti-infection treatment.Results Preoperative administration of 0.5 ～ 2h efficiency was 97.4％,preoperative 3 ～ 24h efficiency was 94.5％,both difference was statistically significant(x2 =4.97,P ＜0.05) ; medication persistence time ＜ 24h effective rate reached 92.3％,medication duration 24h to 3d efficiency 96.8％,use duration of 4 ～7d effective rate was 83.5％,the use of antibiotics of short duration group had significantly higher efficiency long service group,significant difference (x2 =6.19,P ＜0.05).A,B,C group combined medication against infection of total effectiveness respectively was 95.3％,94.5％,95.2％,which was not statistically significant (F =0.16,P ＞ 0.05).Conclusion Operation before the use of antibiotic prophylaxis against infection effect is good,several antibiotics combined with medication regimens has no significant difference in efficiency.