Clinical efficacy of tangmaikang for treating with early diabetic nephropathy and its impact on oxidative stress / 中国基层医药

ABSTRACT

Objective To observe the clinical efficacy of Tangmaikang in the treatment of early diabetic nephropathy,and explore the impact of oxidative stress for patients.Methods 94 patients with early diabetic nephropathy were randomly divided into two groups,the control group (n =47) was treated with conventional therapy while the study group (n =47) was given Tangmaikang on the basis of the conventional group,all of the patients was treated for 8 weeks.After the end of treatment,the clinical efficacy and changes in oxidative stress indicators were evaluated.Results The total effective rate of the study group(91.5％) was significantly higher than that of the control group (68.1％),there was statistically significant difference (x2 =57.31,P ＜0.05).The serum superoxide dismutase (SOD) of the study group increased to (81.2 ± 8.9)μU/L,catalase (CAT) increased to (27.3 ± 2.5)μU/L,malondialdehyde(MDA) decreased to (4.9± 0.5)μmol/L,and there were statistically significant differences compared with the control group(t =3.01,2.75,2.14,all P ＜0.05).Conclusion Tangmaikang in the treatment of early diabetic nephropathy has good effect,which plays a renoprotective effect on inhibiting oxidative stress.