Clinical application of combined detection of serum tumor markers in diagnosis of lung cancer / 中国基层医药
Chinese Journal of Primary Medicine and Pharmacy
; (12): 2775-2776, 2013.
Article
in Zh
| WPRIM
| ID: wpr-436774
Responsible library:
WPRO
ABSTRACT
Objective To investigate the significance of combined detection of serum tumor markers in the diagnosis of lung cancer,and to select the most sensitive serum tumor markers.Methods Enzyme-linked immunosorbent assay was used to detect the serum tumor markers of 62 lung cancer patients and 62 healthy persons,who were neuron specific enolase enzyme (NES),carbohydrate antigen 125 (CA 125),cytokeratin 19 (CYFRA21-1) and carcinoembryonic antigen(CEA).Results The level of serum CEA,CA125,CYFRA21-1,and NES of the lung cancer group were all higher than those of the control group (all P < 0.05).Among the four kinds of tumor markers,CA125 had the highest sensitivity(59.7%),which was followed by CEA(53.2%).The sensitivity of the four kinds of joint detection was 87.1%,the highest sensitivity of three markers joint detection was CEA + CA125 + CYFRA21-1 (87.1%),while that of the two kinds of joint detection was CEA + CA125 (75.8%).Conclusion There are high clinical significance in the diagnosis of lung cancer with four kinds of serum tumor markers,CEA + CA125 + CYFRA21-1 can be used as the best markers for joint detection of lung cancer with high sensitivity.
Full text:
1
Index:
WPRIM
Type of study:
Diagnostic_studies
Language:
Zh
Journal:
Chinese Journal of Primary Medicine and Pharmacy
Year:
2013
Type:
Article