Kidney deficiency resulting in fear stress: an evidence from behavior experiment on animal model / 国际中医中药杂志

ABSTRACT

Objective To analyze the correlation between kidney deficiency and fear stress by investigating the difference in behavior between groups of model rats.Methods The rats were divided randomly into 3 groups.To create kidney deficiency models as the experimental group by intramuscular injection of hydrocortisone; giving high-fat and high-salt diet by gastric perfusion to create spleen deficiency models as the control group; normal rats were used as the blank control group.Using light stimulation,thermo stimulation and food stimulation as the factors,to observe and analyze the difference of behavior among groups under each type of environmental stimulus.Results The behavior experiment showed the difference among groups,both kidney deficiency group and spleen deficiency group acted out more apparent fear stress than normal group (without food stimulation P=0.039,with food stimulation P=0.037).For example,under the environmental stimulus of light and no food,3 groups leaned out for different frequency in 15 min:normal group showed(5.70± 1.636)times,spleen deficiency group showed(2.30±0.949)times and kidney deficiency group showed (0.05±0.224)times,which demonstrated fear stress and physical constitution are relevant; kidney deficiency group showed the most obvious fear stress among 3 groups,which proved the correlation between kidney deficiency and fear stress was more significant.Conclusion Kidney deficiency was a significant factor of fear stress,the correlation between them could be direct.