Associations of anti-Smith antibo dies with clinical manifestations and disease activity in children with systemic lupus erythematosns / 中华皮肤科杂志
Chinese Journal of Dermatology
;
(12): 667-669, 2013.
Article
in Chinese
| WPRIM
| ID: wpr-437266
ABSTRACT
Objective To assess the associations of anti-Smith antibodies with clinical manifestations and disease activity in children with systemic lupus erythematosus (SLE).Methods According to SLE disease activity index (SLEDAI) score,72 children with SLE were divided into the active group and inactive group.An immunoblotting method was used to detect serum anti-Smith antibodies in these subjects.Chi-square test was conducted to assess the associations of anti-Smith antibodies with clinical manifestations and disease activity in these patients.Results Of these patients,28 (38.9%) were assigned into the inactive group,and 44 (61.1%) to the active group.Anti-Smith antibodies were detected in 17 (23.6%) patients,but not in the other 55 (76.4%) patients.Elevated incidence rate of kidney injury was observed in anti-Smith antibody-positive patients compared with anti-Smith antibody-negative patients (70.6% (12/17) vs.41.8% (23/55),P < 0.05).Meanwhile,the positivity rate of anti-Smith antibodies was 31.8% (14/44) in the active group,significantly higher than that in the inactive group (10.7%,3/28,P < 0.05).Conclusions Anti-Smith antibodies are not only an important indicator for the diagnosis of SLE,but also a risk factor for disease exacerbation and kidney injury in children with SLE.
Full text:
Available
Index:
WPRIM (Western Pacific)
Type of study:
Risk factors
Language:
Chinese
Journal:
Chinese Journal of Dermatology
Year:
2013
Type:
Article
Similar
MEDLINE
...
LILACS
LIS