Long-term anti-epileptic drug therapy and metabolic bone disase in children / 国际儿科学杂志
International Journal of Pediatrics
;
(6): 345-348, 2013.
Article
in Chinese
| WPRIM
| ID: wpr-437368
ABSTRACT
Epilepsy is a common chronic brain dysfunction in children.Studies have showed that antiepileptic drugs (AED) affect the hydroxylation of vitamin D in liver and kidney and inhibit the calcification of bone,mainly by up-regulating cytochrome oxidase P450 and promoting the resolution of vitamin D,and then increasing serum parathyroid hormone compensatory.Long-term use can cause children metabolic bone disease occurrence,clinical manifestations include bone pain,short stature,rickets,teeth agenesis,fracture,etc.AED firstly affect the hormones related to bone metabolism in vivo,so that the present researches focus on biochemical tests and measurement of sclerotin and bone density.In the children's long-term use of antiepileptic drug treatment at the same time,the application of Vitamin D,calcium and exercise can prevent the occurrence of metabolic bone disease.
Full text:
Available
Index:
WPRIM (Western Pacific)
Language:
Chinese
Journal:
International Journal of Pediatrics
Year:
2013
Type:
Article
Similar
MEDLINE
...
LILACS
LIS