DNA methylation and congenital heart disease pathogenesis / 国际儿科学杂志
International Journal of Pediatrics
;
(6): 370-374, 2013.
Article
in Chinese
| WPRIM
| ID: wpr-437378
ABSTRACT
The roles that DNA methylation play in the congenital heart disease have recently begun to come to light.The abonormal DNA meghylation pattern on key regulation gne during heart development,such as T-box,CHD7,LINE1,methylenetrahydrofolate reductase,changed the expression of those gene,and increased the incidence of the congenital heart disease.The DNA methylation could be determined by sequencing,methylationsensitive PCR and combined bisulfate restriction anylysis.To study the DNA methylation will not only reveal the mechanism of congenital heart disease,but also provide a new strategy for clinical diagnosis and treatment.
Full text:
Available
Index:
WPRIM (Western Pacific)
Type of study:
Etiology study
Language:
Chinese
Journal:
International Journal of Pediatrics
Year:
2013
Type:
Article
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